Release time：2024-09-13 Source：Xurui Biotechnology
Dengue fever outbreak in the Philippines has declared a state of disaster, with multiple confirmed cases in Guangdong and Zhejiang provinces
Due to the increasing number of dengue fever cases, on September 8th local time, the province of Bohua in central Philippines entered a state of disaster. Since the beginning of this year, there have been over 130000 confirmed cases of dengue fever in the Philippines, and some provinces and cities have declared a state of disaster due to the surge in dengue fever cases.
Recently, multiple cases of dengue fever infection after overseas travel have been reported by domestic disease control departments in Zhejiang, Guangdong, and other places. Some cases of fever did not actively inform their travel history when seeking medical treatment, resulting in delayed diagnosis and treatment, which can easily cause local transmission and affect the health of others. In response to this risk, local disease control has issued emergency reminders and announcements to monitor the risk.
01 What is dengue fever?
Dengue fever is an acute infectious disease caused by dengue virus and transmitted by Aedes aegypti or Aedes albopictus. It is characterized by high fever, rash, severe muscle and joint pain, facial and conjunctival congestion, redness of the neck and upper chest skin, accompanied by lymph node enlargement, decreased white blood cells, and other symptoms. This disease is prone to occur during the summer, autumn, and rainy seasons, and can affect people of all ages and genders.
What are the main transmission vectors of dengue fever?
Patients and latent carriers are the main sources of dengue fever transmission, with the main vectors being Aedes aegypti and Aedes albopictus.
What are the main clinical manifestations of dengue fever?
The incubation period of dengue fever is 3-15 days, usually 5-8 days. The typical symptoms of dengue fever are "high fever, three pains, three redness, and rash".
High fever: sudden high fever (body temperature can reach 40 ℃ within 24 hours).
Three pains: severe headache, orbital pain, and overall muscle and joint pain.
Three redness: facial, neck, and chest flushing.
Rash: Congestion rash or punctate hemorrhagic rash appearing on the limbs, trunk, or head and face.
04 What are the laboratory inspection items in?
Blood routine: Decreased white blood cells and platelets, and the degree of platelet decline is proportional to the severity of the condition;
Biochemistry: More than half of patients will experience mild to moderate elevation of ALT and AST, with AST showing a more significant increase than ALT. Some patients may also experience elevation of myocardial enzymes and blood creatinine;
Etiology: ① DENV-NS1 antigen: usually positive within 7 days of onset, used for early diagnosis of dengue fever. The positive rate is over 90% when infected for the first time, and only 60% to 80% when infected again;
② DENV IgM: can be detected as early as 4 days after onset, used for early diagnosis of dengue fever;
③ DENV IgG: A positive result with a single test titer ≥ 1:80 indicates a previous infection. If the titer increases by four times or more during the recovery period compared to the acute period, a recent infection can be diagnosed;
④ Nucleic acid testing: RT-PCR can be used to detect DENV in the early stages of the disease;
⑤ Virus isolation: DENV can be isolated and cultured from the blood, cerebrospinal fluid, or tissues of patients in the acute phase.
